top-100 public hub v1

thesis -> mechanism -> lever -> one step

• thesis: публичный набор должен быть не россыпью ссылок, а одной входной дверью: что читать, в каком порядке, и что уже locked vs что еще draft.
• mechanism: собираем current public surfaces вокруг top-100, v2 methodology, system-age, and current sendout.
• lever: это снижает путаницу между methodology, current doctrine, public top-100 surface, и exact final scorecard, который еще не опубликован.
• one step: читать по порядку ниже.

what is already public

1) methodology + provenance review

• what it is:
• как мы вообще собирали top-100
• на что опирались
• где strong provenance
• где research debt
• open:
• top-100 methodology + provenance review

2) selection framework v2

• what it is:
• новый canonical doctrine для high-stress / high-travel founder cohort
• цена убрана из scoring
• biomarkers vs derivations vs companion modules разведены
• open:
• top-100 selection framework v2

3) rerun protocol v2

• what it is:
• как именно пересобирать exact top-100 после research refresh
• какие deliverables обязаны выйти
• open:
• top-100 rerun protocol v2

4) system-age model v2

• what it is:
• как top-100 должен кормить Health
• почему endocrine / recovery теперь выше по весу
• как attached vascular / visible-aging companions живут рядом с blood model
• open:
• system age contribution model v2

5) current high-stress top-100 surface

• what it is:
• визуальный current public surface про v2-shift
• lifted markers
• HPA logic
• male / female overlays
• open:
• top framework v2 high-stress achievers

6) current blood+urine sendout surface

• what it is:
• текущий public lab-facing grouped list
• useful when you want a practical sendout / quotation surface now
• open:
• top-100 blood + urine lab sendout

reading order

1. methodology review
2. selection framework v2
3. rerun protocol v2
4. system-age model v2
5. high-stress top framework surface
6. lab sendout surface

important honesty line

• current public package is strong on doctrine.
• current public package is not yet the final exact locked top100_biomarker_scorecard_v2.csv.
• the exact board-locked v2 count still needs:
• final per-marker scorecard
• board decision artifact
• closure of current provenance gaps around HPA / SNS and several promoted v2 markers

what is already locked

• price is out of scoring
• exact top-100 count applies only to orderable lab biomarkers
• testosterone closure requires total T + SHBG + albumin -> free T
• HPA best-read block is:
• cortisol_am
• cortisol_pm
• spot_urinary_cortisol_creatinine
• urinary_metanephrines_fractionated
• urinary_3_methoxytyramine
• 24h urinary free cortisol is not default baseline
• PWV is the default vascular-elasticity companion signal
• skin / dermoscopy / face / hair are mandatory companion longitudinal layers

what is next

• publish top100_biomarker_scorecard_v2.csv
• publish top100_biomarker_board_decisions_v2.md
• then update this hub so the exact locked v2 top-100 becomes the first link, not the missing next step